Not in Italy anyway.
This most iconic of Italian-American dishes, spaghetti and meatballs, is considered a weird and laughable combination by Italians.
You can have your spaghetti as a primo (first course) and then you can order those meatballs (polpette as they're called in Italy) as a stand-alone second course in a variety of sauces and preparations.
The Manhattan location (300 Spring St in the West Village) of Rome's famed Sora Lella restaurant
serves this authentic version of polpette in white wine sauce --a wondrous example of doing meatballs as the Romans do.